Kazuhiko Yanai Selected Research

Histamine H1 Receptors (Histamine H1 Receptor)

1/2022	Histamine Neuroimaging in Stress-Related Disorders.
1/2022	Efficacy and Safety of Non-brain Penetrating H1-Antihistamines for the Treatment of Allergic Diseases.
1/2012	Roles of histamine in exercise-induced fatigue: favouring endurance and protecting against exhaustion.
3/2011	Brain histamine H1 receptor occupancy of loratadine measured by positron emission topography: comparison of H1 receptor occupancy and proportional impairment ratio.
2/2009	Increased brain histamine H1 receptor binding in patients with anorexia nervosa.
3/2007	[Molecular imaging of histamine receptors in the human brain].
1/2007	The physiological and pathophysiological roles of neuronal histamine: an insight from human positron emission tomography studies.
11/2005	Enhanced antinociception by intracerebroventricularly administered orexin A in histamine H1 or H2 receptor gene knockout mice.
11/2003	[A potential of positron emission tomography in the drug development of non-sedative antihistamines].

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Kazuhiko Yanai Research Topics

Disease

44	Alzheimer Disease (Alzheimer's Disease) 10/2022 - 11/2005
19	Cognitive Dysfunction 10/2022 - 03/2002
15	Amyloid Plaque 09/2015 - 03/2004
13	Dementia (Dementias) 10/2022 - 07/2009
13	Sleepiness 01/2019 - 03/2002
8	Pain (Aches) 01/2017 - 06/2002
7	Gliosis 10/2022 - 01/2018
5	Schizophrenia (Dementia Praecox) 01/2021 - 08/2004
4	Tauopathies 01/2021 - 01/2014
4	Allergic Rhinitis 01/2019 - 10/2005
4	Parkinson Disease (Parkinson's Disease) 02/2017 - 09/2009
3	Urticaria (Hives) 01/2022 - 11/2003
3	Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome) 01/2022 - 01/2018
3	Fatigue 01/2022 - 11/2003
3	Nervous System Diseases (Neurological Disorders) 01/2021 - 02/2019
3	Neoplasms (Cancer) 12/2018 - 11/2012
3	Proteostasis Deficiencies 01/2018 - 11/2009
3	Disease Progression 11/2017 - 06/2014
3	Hypersensitivity (Allergy) 10/2017 - 06/2002
3	Memory Disorders (Memory Loss) 03/2006 - 10/2002
2	Anorexia Nervosa 01/2022 - 02/2009
2	Sleep Deprivation 01/2022 - 01/2010
2	Irritable Bowel Syndrome (Syndrome, Irritable Bowel) 01/2022 - 01/2016
2	Seasonal Allergic Rhinitis (Hay Fever) 01/2022 - 10/2017
2	Atopic Dermatitis (Atopic Eczema) 01/2022 - 10/2017
2	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2022 - 01/2018
2	Brain Ischemia (Cerebral Ischemia) 01/2022 - 10/2002
2	Corticobasal Degeneration 01/2021 - 11/2016
2	Narcolepsy 01/2021 - 02/2009
2	Frontotemporal Dementia (Semantic Dementia) 01/2018 - 05/2014
2	Multiple System Atrophy 02/2017 - 06/2010
2	Neck Pain (Cervicalgia) 01/2017 - 11/2011
2	Sarcopenia 02/2014 - 12/2013
2	Amyloidosis 01/2012 - 05/2010
2	Hyperalgesia 06/2011 - 01/2002
2	Epilepsy (Aura) 03/2006 - 11/2004
1	Neuroinflammatory Diseases 08/2022
1	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2022
1	Food Hypersensitivity (Food Allergy) 01/2022
1	Motion Sickness (Airsickness) 01/2022
1	Tachycardia (Tachyarrhythmias) 01/2022
1	Major Depressive Disorder (Major Depressive Disorders) 01/2022
1	Insulin Resistance 01/2021
1	Brain Diseases (Brain Disorder) 02/2019
1	Carcinoma (Carcinomatosis) 12/2018
1	Vascular Dementia (Subcortical Arteriosclerotic Encephalopathy) 09/2018
1	Astrocytoma (Pilocytic Astrocytoma) 06/2018
1	Glucose Intolerance 01/2018

Drug/Important Bio-Agent (IBA)

28	Amyloid (Amyloid Fibrils)IBA 10/2022 - 04/2007
27	Histamine (Histamine Dihydrochloride)FDA Link 01/2022 - 01/2002
12	Histamine Antagonists (Antihistamines)IBA 01/2019 - 12/2002
11	THK5351IBA 08/2022 - 02/2016
9	Monoamine Oxidase (MAO)IBA 10/2022 - 01/2018
9	Biomarkers (Surrogate Marker)IBA 10/2022 - 09/2006
9	Histamine H1 Receptors (Histamine H1 Receptor)IBA 01/2022 - 11/2003
8	Pharmaceutical PreparationsIBA 02/2019 - 03/2002
7	BenzoxazolesIBA 11/2014 - 03/2004
7	2- (2- (2- dimethylaminothiazol- 5- yl)ethenyl)- 6- (2- (fluoro)ethoxy)benzoxazoleIBA 08/2013 - 04/2007
6	Glucose (Dextrose)FDA LinkGeneric 01/2021 - 11/2011
6	Donepezil (Aricept)FDA LinkGeneric 04/2012 - 10/2002
5	Proteins (Proteins, Gene)FDA Link 01/2022 - 01/2011
5	Histamine H1 AntagonistsIBA 10/2017 - 12/2002
5	tau Proteins (tau Protein)IBA 04/2016 - 11/2005
5	Hypnotics and Sedatives (Sedatives)IBA 01/2016 - 08/2004
3	quinolineIBA 10/2022 - 11/2005
3	Histamine H3 Receptors (Histamine H3 Receptor)IBA 01/2021 - 11/2004
3	SynucleinsIBA 02/2017 - 11/2009
3	fexofenadine (Allegra)FDA LinkGeneric 02/2015 - 12/2002
3	Non-Sedating Histamine H1 Antagonists (Histamine H1 Antagonists, Non Sedating)IBA 02/2015 - 08/2004
3	2- (4- aminophenyl)- 6- (2- fluoroethoxy)quinolineIBA 05/2014 - 04/2011
3	Pyrilamine (Mepyramine)FDA Link 06/2011 - 01/2007
3	OrexinsIBA 01/2010 - 11/2005
3	Amyloid beta-PeptidesIBA 10/2009 - 01/2007
3	Cetirizine (Zyrtec)FDA LinkGeneric 10/2009 - 12/2002
2	Biological ProductsIBA 01/2022 - 08/2013
2	Loratadine (Alavert)FDA Link 01/2019 - 03/2011
2	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 01/2018 - 08/2013
2	benzimidazoleIBA 02/2014 - 11/2005
2	Cholinesterase Inhibitors (Anticholinesterases)IBA 01/2012 - 10/2002
2	Cholinergic Agents (Cholinergics)IBA 01/2012 - 04/2008
2	LigandsIBA 04/2011 - 11/2009
2	Chlorpheniramine (Chlorphenamine)FDA LinkGeneric 03/2011 - 03/2002
2	alpha-SynucleinIBA 06/2010 - 09/2009
2	Prion ProteinsIBA 05/2010 - 11/2009
2	thioperamideIBA 09/2009 - 03/2006
2	Doxepin (Mareen)FDA LinkGeneric 02/2009 - 01/2007
2	AminesIBA 02/2009 - 08/2004
2	Dopamine (Intropin)FDA LinkGeneric 01/2007 - 09/2006
2	Acetylcholine (Acetylcholine Chloride)FDA Link 01/2007 - 03/2006
1	AntiemeticsIBA 01/2022
1	Histidine (L-Histidine)FDA Link 01/2022
1	Cholinergic Antagonists (Anticholinergics)IBA 01/2022
1	Indicators and Reagents (Reagents)IBA 01/2022
1	pitolisantIBA 01/2021
1	Heparitin Sulfate (Heparan Sulfate)IBA 01/2021
1	desloratadine (Aerius)FDA LinkGeneric 01/2019
1	Neuroprotective AgentsIBA 09/2018
1	Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)IBA 09/2018

Therapy/Procedure

7	Therapeutics 01/2019 - 11/2009
2	Spinal Manipulation 01/2017 - 11/2011